A New Method for Mammalian Decerebration
نویسنده
چکیده
In the method to be described the brain stem is nearly encircled by a ligature passed about it through suitable openings made in the skull. Its free ends emerge through the roof of the mouth. When the ligature is drawn down tightly against the floor of the skull the brain stem is severed and the vessels at the base of the brain are compressed. The only special instrument required is a drill made from a steel rod, about 2 mm. in diameter and 8 cm. long, mounted in a suitable handle; the end of the rod is flattened to about 3 mm., the edges are ground sharp, and the flattened end is ground down, so that a sharp point, about 1 mm. long is left projecting at the center of the cutting edge, to prevent slipping when the drill is being forced through the bone. A hole, large enough to carry a stout ligature, is drilled through the flattened surface, near the tip. Procedure for Decerebrating Cats.--The animal is anesthetized with chloroform or ether and both carotids are damped or tied. Both parietal bones are exposed, and symmetrical trephine openings made, so that the center of each opening is about 1 cm. posterior to the most prominent part of the parietal eminence. The dura is split for a few millimeters on each side, and is separated carefully from the lateral wall of the skull. The drill is threaded with a stout linen ligature and passed directly through the brain substance and falx, low enough to avoid the sagittal sinus and far enough anterior to clear the tentorium. It emerges through the opposite opening in the skull, is freed of the ligature, and withdrawn. One of the projecting ends of the ligature is again threaded into the drill. It is then introduced between the dura and lateral skull wall, and its point allowed to slip down along the tentorium, in contact with the parietal bone. At the base of the skull it comes to
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 37 شماره
صفحات -
تاریخ انتشار 2004